Motif ID: FOX{D1,D2}.p2

Z-value: 1.942


Transcription factors associated with FOX{D1,D2}.p2:

Gene SymbolEntrez IDGene Name
Foxd1 15229 forkhead box D1
Foxd2 17301 forkhead box D2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxd1chr13_+_99124196-0.153.8e-02Click!
Foxd2chr4_-_1145814920.092.1e-01Click!


Activity profile for motif FOX{D1,D2}.p2.

activity profile for motif FOX{D1,D2}.p2


Sorted Z-values histogram for motif FOX{D1,D2}.p2

Sorted Z-values for motif FOX{D1,D2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{D1,D2}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_45559866 28.363 Col5a2
collagen, type V, alpha 2
chr1_-_45559904 28.181 Col5a2
collagen, type V, alpha 2
chr3_+_96361879 27.009 NM_001009935
NM_023719
 Txnip

thioredoxin interacting protein

chr10_+_97028456 25.912 Lum
lumican
chr16_+_48872720 25.045 NM_181596
 Retnlg
resistin like gamma
chr16_+_48872756 23.684 Retnlg
resistin like gamma
chr1_+_51346108 22.264 Sdpr
serum deprivation response
chr1_+_51346086 20.410 Sdpr
serum deprivation response
chr1_-_195068455 20.401 NM_001044751
 Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
chr1_+_51345952 20.280 NM_138741
 Sdpr
serum deprivation response
chr7_-_118089700 19.388 NM_010826
 Mrvi1
MRV integration site 1
chr10_+_96079634 19.220 NM_007569
 Btg1
B-cell translocation gene 1, anti-proliferative
chr1_-_45559700 18.520 Col5a2
collagen, type V, alpha 2
chr1_-_45560001 18.474 NM_007737
 Col5a2
collagen, type V, alpha 2
chr10_+_115254308 18.148 NM_001168679
NM_001168680
NM_146010
 Tspan8


tetraspanin 8


chr6_-_5446277 18.055 NM_013743
 Pdk4
pyruvate dehydrogenase kinase, isoenzyme 4
chr17_+_47641999 17.569 NM_001081635
NM_001081636
 Ccnd3

cyclin D3

chr10_-_117252126 17.374


chr8_-_25549415 17.054 NM_026931
 1810011O10Rik
RIKEN cDNA 1810011O10 gene
chr8_-_25549374 16.429 1810011O10Rik
RIKEN cDNA 1810011O10 gene

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 122 entries
Enrichment   P-value GO Accession GO Term
16.58 3.52e-02 GO:0030540 female genitalia development
13.81 1.21e-02 GO:0010761 fibroblast migration
6.98 1.90e-02 GO:0045661 regulation of myoblast differentiation
5.74 3.35e-02 GO:0010717 regulation of epithelial to mesenchymal transition
4.80 2.60e-02 GO:0048641 regulation of skeletal muscle tissue development
4.68 3.43e-02 GO:0050818 regulation of coagulation
4.68 3.43e-02 GO:0051153 regulation of striated muscle cell differentiation
4.07 3.06e-02 GO:0010906 regulation of glucose metabolic process
3.68 4.81e-02 GO:0007160 cell-matrix adhesion
3.35 1.33e-02 GO:0031589 cell-substrate adhesion
3.01 1.37e-04 GO:0043434 response to peptide hormone stimulus
2.71 1.31e-02 GO:0042060 wound healing
2.69 4.73e-06 GO:0001501 skeletal system development
2.64 1.35e-02 GO:0006916 anti-apoptosis
2.49 2.06e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.43 1.59e-02 GO:0034097 response to cytokine stimulus
2.35 3.19e-06 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
2.35 2.07e-04 GO:0001944 vasculature development
2.34 9.53e-04 GO:0001568 blood vessel development
2.33 5.64e-05 GO:0009725 response to hormone stimulus

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
Enrichment   P-value GO Accession GO Term
7.65 2.08e-02 GO:0005583 fibrillar collagen
5.10 3.70e-02 GO:0005581 collagen
2.83 7.95e-03 GO:0044420 extracellular matrix part
2.40 1.37e-03 GO:0016323 basolateral plasma membrane
2.29 4.69e-02 GO:0031252 cell leading edge
2.22 3.89e-04 GO:0042598 vesicular fraction
2.22 4.98e-04 GO:0005792 microsome
2.00 3.58e-07 GO:0005615 extracellular space
1.90 3.80e-08 GO:0044421 extracellular region part
1.73 2.53e-03 GO:0044451 nucleoplasm part
1.59 2.78e-07 GO:0005576 extracellular region
1.49 1.31e-02 GO:0000267 cell fraction
1.29 7.06e-06 GO:0005634 nucleus
1.24 4.99e-03 GO:0044422 organelle part
1.22 4.04e-02 GO:0044446 intracellular organelle part
1.21 1.09e-08 GO:0043226 organelle
1.21 5.51e-07 GO:0043227 membrane-bounded organelle
1.21 7.91e-07 GO:0043231 intracellular membrane-bounded organelle
1.21 2.89e-03 GO:0044444 cytoplasmic part
1.20 6.15e-08 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
Enrichment   P-value GO Accession GO Term
6.03 1.56e-02 GO:0005520 insulin-like growth factor binding
3.87 6.06e-03 GO:0005496 steroid binding
3.63 3.31e-05 GO:0019838 growth factor binding
2.79 1.71e-02 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
2.09 6.30e-03 GO:0008134 transcription factor binding
2.00 2.12e-03 GO:0008289 lipid binding
1.96 4.36e-02 GO:0016564 transcription repressor activity
1.89 9.41e-05 GO:0043565 sequence-specific DNA binding
1.88 1.20e-05 GO:0001071 nucleic acid binding transcription factor activity
1.88 1.20e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.72 1.65e-04 GO:0030528 transcription regulator activity
1.67 1.98e-04 GO:0005102 receptor binding
1.65 3.04e-03 GO:0019899 enzyme binding
1.48 3.43e-04 GO:0003677 DNA binding
1.38 4.69e-04 GO:0003676 nucleic acid binding
1.37 1.47e-12 GO:0005515 protein binding
1.21 1.70e-12 GO:0005488 binding